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HCAb-PLUS

HBICE® Bi/Multi-Specific

Step one

Antibody Discovery

Leveraging Harbour Mice® platforms and expertise, Nona provides a complete solution for fully human H2L2, HCAb, and bi/multi-specific antibody discovery, including antigen preparations, immunization, antibody screening, engineering, and functional evaluation.

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H2L2
HCAb
HBICE
Step two

ADC Bioconjugation

Nona offers a variety of bioconjugation technologies such as lysine/cysteine-based conjugation with optimized DAR value and optimization of reaction conditions. Our proprietary DAR2 site-specific conjugation and linker-payload library include the majority of classical linker-payloads, like cleavable and non-cleavable linkers.

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step Three

ADC Biophysical Characterizations

Based on Nona’s deep understanding of ADC molecules, we perform a comprehensive assessment of molecules for lead identification and characterization, including DAR determination, conjugation stability, plasma stability and drug-releasing efficiency.

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HCAb-Based Immune Cell Engager

Nona Biosciences’ proprietary HBICE® (HCAb-Based Immune Cell Engager) platform, built upon Harbour Mice® platforms, enables the development of novel bispecific, multispecific and multivalent antibodies with simplified structures, smaller molecule size, and fewer polypeptide chains. With the HBICE® platform, we can quickly create multispecific antibodies that redirect immune cells to the tumor microenvironment (TME) for effective tumor eradication.

HBICE® molecules are designed to recognize and bind specific tumor-associated antigens (TAAs) on tumor cells, as well as CD3 on T cells or other stimulatory molecules on immune cells like NK cells or myeloid cells. This dual recognition leads to the activation of immune cells within the TME, selectively engaging anti-tumor immunity while avoiding non-specific activation of peripheral immune cells. Furthermore, the HBICE® technology allows for the generation of molecules with different structure and avidities, enabling unique mechanisms of action that cannot be achieved by combination therapies.

The diagrams below depict illustrative scenarios: by circumventing the conventional T-cell activation pathway, typically mediated by the TCR-MHC interaction, HBICE® molecules with CD3-targeting capabilities can induce a broad T-cell response that is not restricted by MHC, effectively overcoming immune escape mechanisms like antigen presentation downregulation. Within the tumor microenvironment (TME), T cells often lack essential costimulatory signals for optimal functionality. HBICE® antibodies, designed to target tumor-associated antigens (TAAs) and provide the essential costimulatory signal for full T cell activation in TAA-dependent manner. This mechanism results in the effective eradication of tumors and an enhanced safety profile.

Figure 1: Novel HBICE®

HBICE® MOA 1

HBICE® MOA 2

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Having questions? Contact us at BD@nonabio.com

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