Nona can assist you in every step of the ADC process.

Clinically validate fully human antibody platform

Antibody Discovery

Leveraging Harbour Mice® platforms and expertise, Nona provides a complete solution for fully human H2L2, HCAb, and bi/multi-specific antibody discovery, including antigen preparations, immunization, antibody screening, engineering, and functional evaluation.

Extensive experience and a variety of established bioconjugation technologies

ADC Bioconjugation

Nona offers a variety of bioconjugation technologies such as lysine/cysteine-based conjugation with optimized DAR value and optimization of reaction conditions. Our proprietary HCAb-DAR2 site-specific conjugation and linker-payload library include the majority of classical linker-payloads, like cleavable and non-cleavable linkers.

Full array of analytical panel and bioconjugate characterization capabilities

ADC physicochemical characterization

Based on Nona’s deep understanding of ADC molecules, we perform a comprehensive assessment of molecules for lead identification and characterization, including (but not limited to) DAR determination, conjugation stability, conjugation efficiency, aggregation, free drug residue, molecule content, and concentration.

Full range in vitro evaluation and integral capabilities for in vivo studies

ADC In Vitro and In Vivo Characterization

A full range of in vitro bioactivity studies for both monoclonal antibodies and ADCs is available, including antigen binding, internalization, soluble antigen interference, cytotoxicity, and bystander killing. Nona also encompasses integral capabilities for in vivo studies, including various pharmacological models for ADC efficacy assessment, such as CDX, PDX, and heterogeneous tumor models. Additionally, pre-toxicity evaluation and small animal PK studies complete the integrated ADC R&D services.

Integrated Platform for Innovative ADC Discovery

Nona Biosciences provides comprehensive ADC R&D services based on our proprietary and clinically validated fully human H2L2 and HCAb Harbour Mice® and HCAb Plus™ platforms.

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